Understanding the treatment options that are available for your loved one

There are 2 types of medications used to treat Alzheimer’s disease. They work differently and are often used together in patients with moderate to severe Alzheimer's disease. This is called combination therapy.

Type of medication

Acetylcholinesterase inhibitors (AChEIs)
These are thought to work by slowing the breakdown of a chemical in the brain called acetylcholine. This chemical is involved in learning and memory.

Brand name

  • Aricept® (donepezil HCl)*
  • Razadyne® (galantamine HBr)
  • Exelon® (rivastigmine)

Type of medication

Glutamate pathway modifiers (memantine hydrochloride)
These may help regulate the abnormal activity of glutamate—another chemical in the brain that is important for learning and memory.

Brand name

  • NAMENDA® (memantine HCI) and NAMENDA XR® (memantine hydrochloride) extended release are approved for moderate to severe Alzheimer's disease

There is no evidence that NAMZARIC, NAMENDA, NAMENDA XR, or an AChEI prevents or slows the underlying disease process in patients with Alzheimer's disease.

NAMZARIC is the FIRST AND ONLY treatment that combines these 2 types of medicines in a single capsule

NAMZARIC offers combination therapy (NAMENDA XR and donepezil HCl) in a single, once-a-day capsule.

*Aricept® is a trademark used by Eisai Inc. under license from Eisai R&D Management Co., Ltd.

Razadyne® is a registered trademark of Johnson & Johnson.

Exelon® is a registered trademark of Novartis AG Corp.

NAMZARIC is a prescription medicine approved to treat moderate to severe Alzheimer’s disease in patients who are taking donepezil hydrochloride 10 mg.

There is no evidence that NAMZARIC prevents or slows the underlying disease process in patients with Alzheimer's disease.

Important Risk Information

NAMZARIC should not be taken by anyone who: has an allergy to memantine HCl, donepezil HCl, medicines that contain piperidines, or any of the ingredients in NAMZARIC.

Before taking NAMZARIC, tell the doctor about all of the patient’s medical conditions, including:

  • heart problems including an irregular, slow, or fast heartbeat
  • asthma or lung problems
  • seizures
  • stomach ulcers
  • bladder, kidney, or liver problems
  • any surgical, dental, or other medical procedures scheduled when anesthesia may be used

Tell the doctor about all the medicines the patient takes, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of NAMZARIC?

NAMZARIC may cause serious side effects, including:

  • muscle problems in patients given anesthesia
  • slow heartbeat and fainting. This happens
    more often in people with heart
    problems. Call the doctor right away if
    the patient faints while taking
    NAMZARIC.
  • more stomach acid. This raises the
    chance of ulcers and bleeding especially
    when taking NAMZARIC. The risk is
    higher for patients who have had ulcers,
    or
    take aspirin or other NSAIDs.
  • nausea and vomiting
  • difficulty passing urine
  • seizures
  • worsening of lung problems in people
    with asthma or other lung disease

The most common side effects of memantine HCl include: headache, diarrhea, and dizziness.

The most common side effects of donepezil HCl include: diarrhea, not wanting to eat (anorexia), and bruising.

These are not all the possible side effects of NAMZARIC.

Please also see full Prescribing Information, including Patient Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/myAbbVieAssist to learn more.

Expand

USE

NAMZARIC is a prescription medicine approved to treat moderate to severe Alzheimer’s disease in patients who are taking donepezil hydrochloride 10 mg.

There is no evidence that NAMZARIC prevents or slows the underlying disease process in patients with Alzheimer's disease.

Important Risk Information

NAMZARIC should not be taken by anyone who: has an allergy to memantine HCl, donepezil HCl, medicines that contain piperidines, or any of the ingredients in NAMZARIC.

Before taking NAMZARIC, tell the doctor about all of the patient’s medical conditions, including:

  • heart problems including an irregular, slow, or fast heartbeat
  • asthma or lung problems
  • seizures
  • stomach ulcers
  • bladder, kidney, or liver problems
  • any surgical, dental, or other medical procedures scheduled when anesthesia may be used

Tell the doctor about all the medicines the patient takes, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of NAMZARIC?

NAMZARIC may cause serious side effects, including:

  • muscle problems in patients given anesthesia
  • slow heartbeat and fainting. This happens
    more often in people with heart
    problems. Call the doctor right away if
    the patient faints while taking
    NAMZARIC.
  • more stomach acid. This raises the
    chance of ulcers and bleeding especially
    when taking NAMZARIC. The risk is
    higher for patients who have had ulcers,
    or
    take aspirin or other NSAIDs.
  • nausea and vomiting
  • difficulty passing urine
  • seizures
  • worsening of lung problems in people
    with asthma or other lung disease

The most common side effects of memantine HCl include: headache, diarrhea, and dizziness.

The most common side effects of donepezil HCl include: diarrhea, not wanting to eat (anorexia), and bruising.

These are not all the possible side effects of NAMZARIC.

Indication

NAMZARIC is a prescription medicine approved to treat moderate to severe Alzheimer’s disease in patients who are taking donepezil hydrochloride 10 mg.

There is no evidence that NAMZARIC prevents or slows the underlying disease process in patients with Alzheimer's disease.

Please also see full Prescribing Information, including Patient Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/myAbbVieAssist to learn more.